Mitochondrial Biology and Experimental Therapeutics
暫譯: 線粒體生物學與實驗治療學

Oliveira, Paulo J.

Mitochondrial Biology and Experimental Therapeutics
  • 出版商: Springer
  • 出版日期: 2018-12-22
  • 售價: $8,090
  • 貴賓價: 9.5 折 $7,686
  • 語言: 英文
  • 頁數: 708
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3030103587
  • ISBN-13: 9783030103583

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

商品描述(中文翻譯)

本書探討了針對線粒體代謝的治療策略，特別是在該細胞器功能受損的疾病中，並討論了用於創建可商業化的線粒體靶向藥物傳遞平台的有效策略。隨著研究不斷增長，專注於理解線粒體在細胞代謝中的多面向角色、控制與細胞死亡相關的途徑以及離子/氧化還原調節，線粒體的化學-生物相互作用的研究已擴展到各種藥理學和毒理學應用。本書不僅廣泛涵蓋了基本的線粒體生理學，還將這些途徑中的分子相互作用與多種疾病聯繫起來。這是第一本結合了關於基本線粒體生物學的最先進評論、線粒體變化在不同疾病中的角色，以及該細胞器作為藥理學和非藥理學干預以改善人類健康的重要性的書籍。不同的章節突顯了線粒體在藥物開發和臨床應用中的化學-生物聯繫。

作者簡介

Paulo J. Oliveira is recognized for his work as the Coordinator of the Mitochondrial, Metabolism, and Disease Group at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal and is the current Vice-President of the European Society of Clinical Investigation (ESCI). He has previously spent some time at the University of Minnesota Medical School, Duluth, investigating the mitochondrial mechanisms of anthracycline-induced selective cardiotoxicity. Throughout his career, he has been involved in projects in which the objective was to advance fundamental knowledge and methodological aspects of mitochondrial research. His current research interests include the role of mitochondria in cardiovascular and liver diseases, the relationship between mitochondrial remodeling and (cancer) stem cell biology, development of novel mitochondrial-targeted therapeutics, as well as the mechanisms of drug-related mitochondrial toxicity. Dr. Oliveira has co-authored close to 200 publications focusing on mitochondrial research.

作者簡介(中文翻譯)

保羅·J·奧利維拉因其在葡萄牙科英布拉大學神經科學與細胞生物學中心（CNC）擔任線粒體、代謝與疾病小組的協調員而受到認可，並且目前是歐洲臨床研究學會（ESCI）的副會長。他曾在明尼蘇達大學醫學院（Duluth）工作，研究蒽環類藥物引起的選擇性心臟毒性之線粒體機制。在他的職業生涯中，他參與了多個項目，旨在推進線粒體研究的基本知識和方法論方面。他目前的研究興趣包括線粒體在心血管和肝臟疾病中的角色、線粒體重塑與（癌症）幹細胞生物學之間的關係、新型線粒體靶向治療的開發，以及藥物相關的線粒體毒性機制。奧利維拉博士共同撰寫了近200篇專注於線粒體研究的出版物。

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