Drugs and a Methodological Compendium: From Bench to Bedside

Rajput, Vikrant Singh, Runthala, Ashish

Drugs and a Methodological Compendium: From Bench to Bedside
  • 出版商: Springer
  • 出版日期: 2024-09-25
  • 售價: $7,700
  • 貴賓價: 9.5 折 $7,315
  • 語言: 英文
  • 頁數: 425
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 9811979545
  • ISBN-13: 9789811979545

    • 海外代購書籍(需單獨結帳)

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商品描述

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.

商品描述(中文翻譯)

本書提供了從實驗室到臨床的藥物發現與開發的系統性見解。當前的書籍涵蓋了藥物分子發現與開發的幾乎每一個步驟。各章節專注於計算操作模式、藥理優化方法、現代高通量篩選技術及體外程序、結構生物學家在藥物發現與開發中的角色、藥物設計的藥物化學方法、配方與藥物傳遞、候選分子的體內評估、臨床試驗程序等。此外，本書還涵蓋了特定案例研究、監管批准程序以及工業觀點，並與上述概念框架相結合。同時，本書整合了醫學、生物學、藥學、藥理學和計算科學的各個領域，建議作為一個理想的指導，適合包括分子生物學家、生物化學家、藥理學家、藥物化學家、毒理學家、藥物發現與開發研究人員以及所有對這些學科感興趣的學生在內的廣泛讀者群。

作者簡介

Vikrant Singh Rajput graduated with B. Tech in Biotechnology (2010) from Amity University, Noida, UP, India, a Ph.D in Biological Science from CSIR-Indian Institute of Integrative Medicine, Jammu, J&K, India (2017). He was awarded postdoctoral fellowship from Indian Institute of Technology (IIT) Roorkee and Young Scientist Award/Research grant from Department of Health Research (Govt. of India). He has also held different positions like Adhoc Faculty at National Institute of Technology (NIT) Raipur, Project scientist at Biosafety Support Unit, Regional Centre for Biotechnology, Faridabad and Scientist at Foundation for Neglected Diseases Research, Bengaluru. He currently works as Assistant Professor at Dept. of Biomedical Engineering, Central University of Rajasthan Ajmer.

Areas of interest: TB biology; TB and anti-bacterial drug discovery; Technologies evaluating PK/PD of TB drugs, Combatting drug resistance; Novel drug targets; Computational drug discovery and immunoinformatics.


Ashish Runthala graduated with M.Sc. in Biological Science (2005) from BITS Pilani, Rajasthan, India. Meanwhile qualifying the National Eligibility test (NET), he pursued the M.E. in Biotechnology (2008) here and completed Ph.D in Computational Biology in 2016. He was awarded the Ucchayatar Avishkar Yojana (UAY) in 2017 from Indian Institute of Science. Starting his academic responsibilities at BITS Pilani from 2005, he has held several positions viz. Teaching Assistant, Assistant Lecturer, Lecturer and Visiting Faculty. He has also worked at Presidency University Bangalore as an Assistant Professor. He is currently working as an Associate Professor at KL University, Vijayawada, and is doing research on developing the functionally improved enzymes of the DXP pathway for enhancing the overall yield of the pathway.

Areas of interest: Computational algorithms; Bioinformatics; Protein structure prediction; Enzyme design; Decoding active site; Designing thermostable enzyme.


作者簡介(中文翻譯)

Vikrant Singh Rajput於2010年從印度烏塔爾邦諾伊達的阿米提大學獲得生物技術學士學位，並於2017年在印度查謨和克什米爾的CSIR-印度綜合醫學研究所獲得生物科學博士學位。他曾獲得印度理工學院（IIT）魯爾基的博士後獎學金，以及印度政府健康研究部的青年科學家獎/研究補助金。他還曾擔任過多個職位，包括國立技術學院（NIT）賴布爾的臨時教員、生物安全支持單位的項目科學家、以及班加羅爾被忽視疾病研究基金會的科學家。目前，他在拉賈斯坦中央大學阿傑梅爾的生物醫學工程系擔任助理教授。

研究興趣：結核病生物學；結核病及抗菌藥物發現；評估結核病藥物的藥物動力學/藥效學技術；對抗藥物抗性；新型藥物靶點；計算藥物發現與免疫信息學。

Ashish Runthala於2005年從印度拉賈斯坦的比特斯皮拉尼獲得生物科學碩士學位。在通過國家資格考試（NET）後，他在此攻讀生物技術碩士學位（2008），並於2016年完成計算生物學博士學位。他於2017年獲得印度科學院的Ucchayatar Avishkar Yojana（UAY）獎項。自2005年起，他在比特斯皮拉尼開始了學術工作，擔任過多個職位，包括教學助理、助理講師、講師和訪問教員。他還曾在班加羅爾的總統大學擔任助理教授。目前，他在KL大學（維傑亞瓦達）擔任副教授，並進行有關開發功能改進的DXP途徑酶的研究，以提高該途徑的整體產量。

研究興趣：計算算法；生物信息學；蛋白質結構預測；酶設計；解碼活性位點；設計耐熱酶。

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