商品描述
With the advent of next-generation sequencing technologies, the genomic sequences for an ever-expanding number of organisms have been decoded, providing immense databases of protein amino acid sequences and DNA and RNA nucleotide sequences. These databases are allowing comparisons across thousands of species, enabling the identification of those that have undergone significant molecular evolution in specific proteins or RNA molecules. In the 21st century, RNA biology has gained major attention with the discovery of functional non-coding RNAs and regulatory systems including CRISPR. These advances have clarified with high resolution the evolutionary transitions of RNA-related enzymes and RNA-binding proteins, which govern the flow of genetic information. This book provides an in-depth overview on the molecular evolution of RNA-related enzymes, RNA-binding proteins, and RNA regulatory systems. The focus is not only on newly-identified RNA regulatory factors or systems that have garnered attention since the beginning of the 21st century, but it also elucidates RNA-related molecules with fundamental and significant roles in cellular genetic regulation, or the regulatory systems themselves. Specifically, the volume revisits molecules involved in transcription (RNA polymerase), pre-mRNA processing and degradation (ribonucleases such as RNase E, RNase III, and self-cleaving ribozymes), and in translation (ribosomal proteins and translation factors), regardless of their novelty. This volume thus is intended to serve as an essential resource for furthering the systematic understanding of cellular genetic regulation from a molecular evolutionary standpoint.
商品描述(中文翻譯)
隨著新一代測序技術的出現，越來越多生物的基因組序列已被解碼，提供了大量的蛋白質氨基酸序列以及DNA和RNA核苷酸序列的數據庫。這些數據庫使得跨越數千種物種的比較成為可能，從而能夠識別出在特定蛋白質或RNA分子中經歷顯著分子進化的物種。
在21世紀，隨著功能性非編碼RNA和包括CRISPR在內的調控系統的發現，RNA生物學獲得了重大關注。這些進展高解析度地闡明了與RNA相關的酶和RNA結合蛋白的進化過渡，這些分子主導著遺傳信息的流動。
本書深入概述了與RNA相關的酶、RNA結合蛋白和RNA調控系統的分子進化。重點不僅在於自21世紀初以來受到關注的新識別RNA調控因子或系統，還闡明了在細胞遺傳調控中具有基本和重要角色的RNA相關分子，或這些調控系統本身。具體而言，本書重新探討了參與轉錄（RNA聚合酶）、前mRNA處理和降解（如RNase E、RNase III和自切割核酶等核糖核酸酶）以及翻譯（核糖體蛋白和翻譯因子）的分子，無論它們的新穎性如何。因此，本書旨在作為進一步從分子進化的角度系統理解細胞遺傳調控的重要資源。
作者簡介
Akio Kanai was born in Tokyo, Japan. He graduated from Waseda University in 1985 and obtained his PhD in molecular biology at the University of Tokyo in 1990. He finished postdoctoral training at the National Institutes of Health, USA (1990-1992), and he was appointed a researcher in the Tokyo Metropolitan Institute of Medical Science (1992-1996). He was a group leader for the Japan Science and Technology Corporation (JST), ERATO Project Group (1996-2001). He was an Associate Professor at the Institute for Advanced Biosciences, Keio University (2001-2006) and accepted a full professorship in April 2006 (concurrently serves as a professor at the Faculty of Environment and Information Studies, Keio University). Since 2022, he is also a professor of Systems Biology Program, Graduate School of Media and Governance, Keio University. His major research fields include molecular cellular biology and gene regulation in a variety of organisms. His work in life sciences has led him to his present research into RNA-binding proteins and non-coding RNAs. Allen Nicholson is a Professor of Biology in the College of Science and Technology at Temple University. Prior to this appointment Dr. Nicholson was on the Biology faculty at Wayne State University, from 1985-2002. Dr. Nicholson received his bachelor's degree in Chemistry from Cornell University in 1975 and his doctoral degree in Chemistry from the University of Pennsylvania in 1981. He was an NIH postdoctoral fellow at the Rockefeller University (1981-1985) where he developed his interests in RNA function in gene regulation. Although trained as a chemist, Dr. Nicholson established a distinguished career in molecular biology, and his research, which has been funded by the National Institutes of Health, has focused on understanding how genes are expressed and regulated at the post-transcriptional level. Specifically, Dr. Nicholson and his group are studying ribonucleases -- proteins whose role is to recognize and cut RNA molecules, and which exert profound effects on gene expression that controls cell growth and development. A specific ribonuclease under study, ribonuclease III, is a central participant in post-transcriptional gene expression and regulation in bacteria and has family members in eukaryotic systems with essential functions in gene expression and regulation.
作者簡介(中文翻譯)
金井明夫出生於日本東京。他於1985年畢業於早稻田大學，並於1990年在東京大學獲得分子生物學博士學位。他在美國國立衛生研究院完成了博士後訓練（1990-1992），並於1992年至1996年擔任東京醫科科學研究所的研究員。他是日本科學技術振興機構（JST）ERATO計畫小組的組長（1996-2001）。他於2001年至2006年擔任慶應義塾大學先進生物科學研究所的副教授，並於2006年4月接受全職教授職位（同時擔任慶應義塾大學環境與資訊學部的教授）。自2022年以來，他還是慶應義塾大學媒體與治理研究所系統生物學計畫的教授。他的主要研究領域包括分子細胞生物學和各種生物體中的基因調控。他在生命科學方面的工作使他目前的研究集中於RNA結合蛋白和非編碼RNA。
艾倫·尼克爾森是天普大學科學與技術學院的生物學教授。在此任職之前，尼克爾森博士曾於1985年至2002年在韋恩州立大學的生物學系任教。尼克爾森博士於1975年在康奈爾大學獲得化學學士學位，並於1981年在賓夕法尼亞大學獲得化學博士學位。他曾是洛克菲勒大學的國立衛生研究院博士後研究員（1981-1985），在此期間發展了對RNA在基因調控中功能的興趣。儘管受過化學訓練，尼克爾森博士在分子生物學領域建立了卓越的職業生涯，他的研究得到了國立衛生研究院的資助，專注於理解基因如何在轉錄後水平上表達和調控。具體而言，尼克爾森博士及其團隊正在研究核糖核酸酶——這些蛋白質的作用是識別和切割RNA分子，並對控制細胞生長和發展的基因表達產生深遠影響。正在研究的一種特定核糖核酸酶，核糖核酸酶III，是細菌中轉錄後基因表達和調控的核心參與者，並在真核系統中擁有家族成員，對基因表達和調控具有重要功能。
