Intercellular and Interorganellar Transfer and Communication in Biology and Medicine

Kloc, Malgorzata, Kubiak, Jacek Z., Halasa, Marta

Intercellular and Interorganellar Transfer and Communication in Biology and Medicine
  • 出版商: Springer
  • 出版日期: 2024-09-07
  • 售價: $8,800
  • 貴賓價: 9.5 折 $8,360
  • 語言: 英文
  • 頁數: 579
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031620356
  • ISBN-13: 9783031620355
  • 相關分類: GAN 生成對抗網絡

    • 海外代購書籍(需單獨結帳)

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商品描述

This volume covers recent developments on the role, composition, and functional significance of intercellular and interorganellar transfer. It highlights the involvement of intercellular and interorganellar transfer in cell and developmental biology, differentiation, pathogen dissemination, shaping the genetic makeup of organisms, and the development of various diseases.

Animals and plants evolved different communication mechanisms and transfer of molecules and organelles between cells and between organelles within the individual cells. Tunneling nanotubes (TNTs) in animals, discovered as recently as 2004, and their functional equivalent in plants, plasmodesmata, discovered over 100 years ago, are the membranous bridges that mediate the transfer of organelles, membrane patches, vesicles, DNA/RNA, and different molecules between cells. In addition, there are other means of transfer and communication between the cells, such as cytonemes, airinames, extracellular vesicles (exosomes), and others. Variations in cytoskeletal composition, morphology, modality, and connected cells suggest that these structures play a role in development, establishment of cell fate, progenitor cell differentiation, cell reprogramming, ferroptosis, generation of cancer stem cells, and various diseases. The exchange of intact membrane patches (trogocytosis) between cells of the immune system may modify the immune response. Additionally, the transfer of genetic information between nucleus and organelles and cells of different species can shape the species and evolutionary outcome. Viral and bacterial pathogens can hijack the inter-cellular transfer routes to spread more efficiently. Cell-to-cell transfer of animal and plant pathogens can also occur by the virological synapse (VS). These specialized pathogen-induced structures share similarities and differences with neurological and immunological synapses.

商品描述(中文翻譯)

本書涵蓋了關於細胞間和器官間轉移的角色、組成和功能意義的最新發展。它強調了細胞間和器官間轉移在細胞和發育生物學、分化、病原體傳播、塑造生物的基因組成以及各種疾病的發展中的參與。

動物和植物進化出不同的通訊機制，分子和細胞器在細胞間和細胞內的細胞器之間進行轉移。動物中的隧道奈米管（TNTs）最近於2004年被發現，而植物中的等效結構質點連結孔（plasmodesmata）則在100多年前被發現，它們是介導細胞間細胞器、膜片、囊泡、DNA/RNA和不同分子轉移的膜橋。此外，還有其他細胞間轉移和通訊的方式，如細胞突起、空氣突起、細胞外囊泡（外泌體）等。細胞骨架組成、形態、模式和連接細胞的變化表明這些結構在發育、細胞命運的確立、祖細胞分化、細胞重編程、鐵死亡、癌症幹細胞的生成以及各種疾病中發揮作用。免疫系統細胞之間的完整膜片轉移（trogocytosis）可能會修改免疫反應。此外，核和細胞器之間以及不同物種細胞之間的遺傳信息轉移可以塑造物種和進化結果。病毒和細菌病原體可以利用細胞間轉移路徑更有效地傳播。動物和植物病原體的細胞間轉移也可以通過病毒學突觸（VS）進行。這些特殊的病原體誘導結構與神經和免疫突觸有相似之處和差異之處。

作者簡介

Dr. Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University ofTexas, M D Anderson Cancer Center.

Dr. Jacek Z. Kubiak is the Research Director (Professor) at the French National Research Institute CNRS in Rennes, France. His research is devoted to molecular mechanisms of early embryo development, cell cycle regulation, stem cells, cancer cells and the role of macrophages in the innate immune response. He is the author of over 180 highly cited scientific articles and the editor or co-editor of 10 books. He has graduated from the Warsaw University, Poland and worked at the University of Wisconsin-Madison, USA, Marine Biological Laboratory in Woods Hole, USA and in Jacques Monod Institute in Paris, France. He collaborates with research institute WIM-PIB in Warsaw, Poland combining stem cells, wound healing and cancer research with the prospective in medical applications. Since the COVID-19 outbreak, he co-ordinates an international research group focused on SARS-CoV-2 infection in paediatric patients and he follows up this research field.

Marta Halasa earned her PhD in medical and health science from the Medical University of Lublin, Poland, in 2022. Her research during her doctoral studies focused on epigenetic modifiers, particularly histone deacetylases, and their impact on cancer progression and metastasis. During her PhD, she completed a long-term internship at the University of Turku, Finland, where she gained expertise in 3D cell techniques. She also undertook an internal internship at the Military Institute of Medicine in Warsaw, Poland, where she investigated cell-gene therapy in Alzheimer's disease. After completing her PhD, she obtained a postdoctoral fellow position at the Houston Methodist Research Institute, USA. Currently, her research focuses on investigating the role of macrophages in chronic transplant rejection.

作者簡介(中文翻譯)

Dr. Malgorzata Kloc：在完成加拿大的博士後訓練之前，Dr. Kloc曾是波蘭華沙大學動物學系的終身副教授。她還曾在加拿大渥太華的卡爾頓大學生物學系擔任研究助理。在完成博士後訓練期間，Dr. Kloc獲得了卡爾加里大學的AHFMR研究獎和達爾豪斯大學的MRC生物技術培訓獎。她於1987年加入德克薩斯大學安德森癌症中心的分子遺傳學系擔任研究科學家，並於2006年成為生物化學和分子生物學系的副教授。Dr. Kloc於2008年加入休斯頓方法主義研究所。目前，Dr. Kloc是休斯頓方法主義醫院威爾康奈爾細胞與分子生物學教授，並擔任德克薩斯大學安德森癌症中心遺傳學系的兼職教授。

Dr. Jacek Z. Kubiak：是法國國家科學研究中心(CNRS)在雷恩的研究主任(教授)。他的研究致力於早期胚胎發育的分子機制、細胞週期調控、幹細胞、癌細胞以及巨噬細胞在先天免疫反應中的作用。他是超過180篇高引用科學文章的作者，並且是10本書的編輯或合編者。他畢業於波蘭華沙大學，曾在美國威斯康辛大學麥迪遜分校、美國伍茲霍爾海洋生物實驗室以及法國雅克·莫諾研究所工作。他與波蘭華沙的WIM-PIB研究所合作，結合幹細胞、傷口癒合和癌症研究，展望醫學應用。自COVID-19爆發以來，他協調一個國際研究小組，專注於研究SARS-CoV-2在兒科患者中的感染情況，並跟進這一研究領域。

Marta Halasa：於2022年在波蘭盧布林醫學大學獲得醫學和健康科學博士學位。她在博士期間的研究專注於表觀遺傳修飾因子，特別是組蛋白去乙醯化酶，以及它們對癌症進展和轉移的影響。在博士期間，她在芬蘭圖爾庫大學進行了長期實習，獲得了三維細胞技術的專業知識。她還在波蘭華沙的軍事醫學研究所進行了內部實習，研究了細胞基因治療在阿爾茨海默病中的應用。在完成博士學位後，她在美國休斯頓方法主義研究所獲得了博士後研究員職位。目前，她的研究重點是探究巨噬細胞在慢性移植排斥中的作用。

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