Advances in Pharmacokinetics and Pharmacodynamics

Macheras, Panos

Advances in Pharmacokinetics and Pharmacodynamics
  • 出版商: Springer
  • 出版日期: 2024-05-27
  • 售價: $4,350
  • 貴賓價: 9.5 折 $4,133
  • 語言: 英文
  • 頁數: 204
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 3031297482
  • ISBN-13: 9783031297489

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商品描述

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.

商品描述(中文翻譯)

本書提供了藥物動力學（PK）和藥效學（PD）的最新進展的簡明概述。藥物動力學部分涵蓋了生理基礎藥物動力學（PBPK）建模的最新技術（第1章），以及使用PBPK建模評估食物對藥物吸收的影響（第2章）。第3章和第4章描述了生理基礎有限時間藥物動力學（PBFTPK）模型的最新發展及其在藥物動力學數據中的應用。藥效學部分聚焦於PK/PD建模。第5章概述了臨床實踐和研究中的PK/PD建模和模擬。第6章討論了PK/PD研究中遇到的主題/生理變異問題，而第7章回顧了臨床藥理學對藥物開發和監管現代化的影響。本書是藥學科學家的必備參考資料。

作者簡介

Panos Macheras is Emeritus Professor (since September 2014) of the Department of Pharmacy, University of Athens. He is the Founder (1of the Laboratory of Biopharmaceutics and Pharmacokinetics at the University of Athens. He established the PharmaInformatics Unit of the Research and Innovation Center ATHENA; he is currently the Head of the Unit.Adjunct Professor, Department of Pharmaceutical Sciences, State University of New York (SUNY), Buffalo, USA He received his B. Pharm. and Ph.D degree in Pharmaceutical Chemistry from the University of Athens, Greece. He also received a Ph.D degree in Biopharmaceutics-Pharmacokinetics from King's College, University of London, U.K. He has published more than 180 journal articles (more than 6500 citations, h=40) and seven books in the field of Biopharmaceutics-Pharmacokinetics-Pharmacodynamics. His research interests include experimental, theoretical and computational (modeling and simulation) studies on drugdissolution, release, gastrointestinal absorption, protein binding, drug-cyclodextrins interaction, bioequivalence, biopharmaceuitc classification of drugs, pharmacokinetics, fractal and fractional kinetics, applications of fractal concepts in biopharmaceutical systems and nonlinear dynamics. He serves on the Editorial Board of the journals, Pharmaceutical Research, International Journal of Pharmaceutics and European Journal of Pharmaceutical Sciences.

作者簡介(中文翻譯)

Panos Macheras是雅典大學藥學系的名譽教授（自2014年9月起）。他是雅典大學生物製劑學和藥物動力學實驗室的創辦人之一。他建立了雅典研究和創新中心ATHENA的藥物信息學單位，目前擔任該單位的負責人。他還是美國紐約州立大學水牛城分校藥學系的兼職教授。他在希臘雅典大學獲得了藥學學士和博士學位，並在英國倫敦大學國王學院獲得了生物製劑學-藥物動力學的博士學位。他在生物製劑學-藥物動力學-藥物動力學領域發表了180多篇期刊文章（引用次數超過6500次，h指數為40），並出版了七本書籍。他的研究興趣包括藥物溶解、釋放、腸道吸收、蛋白結合、藥物-環糊精相互作用、生物等效性、藥物生物製劑分類、藥物動力學、分形和分數動力學、分形概念在生物製劑系統和非線性動力學中的應用等的實驗、理論和計算（建模和模擬）研究。他是《藥學研究》、《國際藥學雜誌》和《歐洲藥學科學雜誌》的編輯委員會成員。

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