Hypoxia and Cancer Metastasis
暫譯: 缺氧與癌症轉移

Gilkes, Daniele M.

Hypoxia and Cancer Metastasis
  • 出版商: Springer
  • 出版日期: 2019-06-27
  • 售價: $5,230
  • 貴賓價: 9.5 折 $4,969
  • 語言: 英文
  • 頁數: 160
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3030127338
  • ISBN-13: 9783030127336

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商品描述

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions.

Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments.

 

This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

商品描述(中文翻譯)

本書旨在提供一個詳細的回顧，探討低氧在原發性癌症進展至轉移性疾病中的角色。這將使研究人員能夠發現低氧條件下發生的關鍵細胞變化，這些變化在轉移擴散中扮演著重要角色，從低氧誘導因子（hypoxia-inducible factors, HIF-1 和 HIF-2）的激活，到癌細胞中發生的轉錄譜變化，這些變化促進了癌細胞在不利條件下的存活。

讀者將了解在原發腫瘤中成像和量化低氧程度的方法與挑戰。我們將提供對低氧誘導表型的理解，這些表型影響異質性，改變分泌組（secretome）和腫瘤微環境，修飾細胞代謝，並促進免疫抑制和對化療的抵抗。最後，我們將揭示正在制定的治療策略，旨在針對低氧微環境，以期防止轉移並提高標準癌症治療的療效。

本書是有關低氧腫瘤微環境挑戰和複雜性的最新資訊來源。基礎和轉化科學家、博士後研究員、研究生以及對腫瘤轉移過程感興趣的人士，將會發現本書是一本詳細說明低氧如何影響轉移性疾病的參考資料。

作者簡介

Assistant Professor of Oncology
Assistant Professor Chemical and Molecular Engineering
Johns Hopkins University School of Medicine
Baltimore, Maryland
Jayne Koskinas Ted Giovanis Foundation for Health and Policy Partnership

Daniele Gilkes earned her MS in engineering from the University of Florida and her PhD in cancer biology from the University of South Florida. She is currently an assistant professor in the departments of Oncology as well as Chemical and Molecular Engineering at the Johns Hopkins University School of Medicine. Her research goal is to develop a breast cancer research program which utilizes new technologies that can rapidly advance our understanding of how the microenvironment, in particular hypoxia and hypoxia-induced genetic changes, promote breast cancer metastasis. The overall objective is to identify therapeutic strategies that focus on metastasis treatment and prevention strategies for breast cancer patients.

 

Current Research
Seeking to understand the timing and requirements for metastasis.
Using both mathematics and cancer biology to chart the process of metastasis.
These innovate cross-disciplinary studies will accelerate our understanding of metastasis and guide new therapy development to prevent metastasis in breast cancer survivors.

作者簡介(中文翻譯)

助理教授，腫瘤學
助理教授，化學與分子工程
約翰霍普金斯大學醫學院
馬里蘭州巴爾的摩
*Jayne Koskinas Ted Giovanis 健康與政策夥伴基金會*

Daniele Gilkes 在佛羅里達大學獲得工程碩士學位，並在南佛羅里達大學獲得癌症生物學博士學位。她目前是約翰霍普金斯大學醫學院腫瘤學及化學與分子工程系的助理教授。她的研究目標是開發一個乳腺癌研究計劃，利用新技術快速推進我們對微環境，特別是缺氧及缺氧引起的基因變化，如何促進乳腺癌轉移的理解。整體目標是確定針對乳腺癌患者轉移治療和預防策略的治療策略。

目前研究
尋求了解轉移的時間和需求。
利用數學和癌症生物學來描繪轉移過程。
這些創新的跨學科研究將加速我們對轉移的理解，並指導新療法的開發，以防止乳腺癌倖存者的轉移。

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