The Dynamics of Tumor Microenvironment and Therapeutic Targets
暫譯: 腫瘤微環境的動態與治療靶點
Ghosh, Shyamasree, Pal, Sanjima
- 出版商: CRC
- 出版日期: 2025-11-07
- 售價: $5,500
- 貴賓價: 9.5 折 $5,225
- 語言: 英文
- 頁數: 144
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 1032520493
- ISBN-13: 9781032520490
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相關分類:
Machine Learning、Natural Language Processing
海外代購書籍(需單獨結帳)
商品描述
The tumor microenvironment (TME) plays a significant role in influencing tumor aggressiveness and therapeutic outcomes, presenting both challenges and opportunities in oncology. The Dynamics of Tumor Microenvironment and Therapeutic Targets provides a detailed overview of the complex nature of the TME, highlighting its dynamic cellular and molecular components. Each chapter systematically examines a specific element of the TME, outlining its role in tumor initiation, progression, dormancy, and suppression. The book discusses the use of molecular inhibitors that disrupt tumor-promoting interactions within the TME. Additionally, it covers immune therapies designed to reprogram immune cells in the TME to enhance the effectiveness and durability of cancer treatments. This volume also addresses recent advancements in therapeutic strategies targeting the TME, including the incorporation of contemporary computational methods. Notably, the application of artificial intelligence (AI) and machine learning (ML) to TME analysis is explored, showcasing their utility in biomarker discovery and the development of precision oncology tools.
Key Features
- Comprehensive coverage of the cellular and noncellular components of the TME, with an emphasis on their phenotypic and functional heterogeneity.
- Detailed discussion of both targetable and non-targetable elements of the TME and their relevance in therapeutic development.
- A dedicated chapter on AI-/ML-based methodologies for TME profiling, reflecting the emerging role of computational biology in oncology research.
- Critical descriptions of clinical trials targeting various aspects of the TME, alongside a synthesis of relevant translational and preclinical studies.
This volume serves as a valuable resource for graduate students, early career researchers, and established investigators in cancer biology, tumor immunology, and translational oncology. It provides foundational knowledge as well as insights into emerging therapeutic paradigms centered on the TME.
商品描述(中文翻譯)
腫瘤微環境（TME）在影響腫瘤的侵襲性和治療結果方面扮演著重要角色，為腫瘤學帶來了挑戰與機會。《腫瘤微環境的動態與治療靶點》提供了TME複雜性質的詳細概述，突顯其動態的細胞和分子組成。每一章系統地檢視TME的特定元素，概述其在腫瘤啟動、進展、潛伏和抑制中的角色。本書討論了破壞TME內腫瘤促進相互作用的分子抑制劑的使用。此外，還涵蓋了旨在重新編程TME中免疫細胞的免疫療法，以增強癌症治療的有效性和持久性。本卷還探討了針對TME的治療策略的最新進展，包括當代計算方法的應用。特別是，探討了人工智慧（AI）和機器學習（ML）在TME分析中的應用，展示了它們在生物標記發現和精準腫瘤學工具開發中的實用性。
主要特點
- 全面涵蓋TME的細胞和非細胞組件，強調其表型和功能的異質性。
- 詳細討論TME中可靶向和不可靶向元素及其在治療開發中的相關性。
- 專門章節介紹基於AI/ML的TME剖析方法，反映計算生物學在腫瘤學研究中的新興角色。
- 對針對TME各個方面的臨床試驗進行關鍵描述，並綜合相關的轉譯和前臨床研究。
本卷作為癌症生物學、腫瘤免疫學和轉譯腫瘤學的研究生、早期職業研究人員和資深研究者的寶貴資源，提供了基礎知識以及關於以TME為中心的新興治療範式的見解。
作者簡介
Shyamasree Ghosh, MSc, PhD, PGDHE, PGDBI has been working in the capacity of Scientific Officer G at the School of Biological Sciences (SBS), National Institute of Science Education and Research (NISER), Bhubaneswar, Orissa, India, since 2009, an OCC of HBNI, Mumbai. She graduated from the prestigious Presidency College Kolkata, under Calcutta University, in 1998, with honours in zoology, with chemistry and physiology as additional subjects, and was awarded the prestigious National Scholarship from the Government of India in the same year. She completed her postgraduate studies in biotechnology at Calcutta University, ranking second in the university in 2000.
She completed her PhD from the Indian Institute of Chemical Biology (IICB), CSIR, Kolkata, after qualifying for the National Eligibility Test conducted by the Ministry of HRD, Government of India. Her PhD work in 2005 in the field of childhood acute lymphoblastic leukemia (ALL) was published in various national and international journals of repute. Later, she worked in the field of stem cells and nanotechnology during her postdoctoral research as a Stem Cell Scientist at Manipal Health Systems, Bangalore, and the Indian Association for the Cultivation of Sciences (IACS), Kolkata. She served as the Head of the Biotechnology Department in a postgraduate college affiliated with Bangalore University until 2009.
She has authored and edited 16 books, both as a single author and jointly with other co-authors. Her publications have been widely cited globally, and she has received several awards in India for her academic endeavours.
Sanjima Pal, MSc, PhD, is currently working as a Research Associate (Staff Scientist) at the Research Institute of the McGill University Health Centre (RI-MUHC) in Canada. She leads a project focused on developing a patient-specific, tumor-microenvironment-inclusive organ-on-chip platform to predict individualized chemosensitivity. Additionally, she is investigating altered lipid metabolism as a driver of chemoresistance and a potential therapeutic target in gastroesophageal cancer.
She earned her doctoral degree in immune-chemical biology in 2017 from the School of Biological Sciences (SBS) at the National Institute of Science Education and Research (NISER), Bhubaneswar, Odisha, India. From 2016 to 2017, she worked as a Research Associate at the Crystallography and Molecular Biology Division of the Saha Institute of Nuclear Physics, Kolkata.
She completed a postdoctoral research training in the Department of Radiation Oncology at the University of Michigan, Ann Arbor (2017-2020), where she contributed to a drug discovery project focused on developing a novel class of small molecules designed to degrade EGFR by disrupting its dimerization. During her second postdoctoral fellowship at McGill University, she established a microfluidic organ-on-chip platform capable of simulating clinical conditions for modeling esophageal adenocarcinoma.
She is currently a member of a clinical trial team, contributing to the analysis of immune landscapes in patients with gastroesophageal adenocarcinoma undergoing perioperative chemo-immunotherapy. Her work has been widely cited, and she has presented her research at numerous national and international conferences. She has received several awards and fellowships in recognition of her academic achievements.
作者簡介(中文翻譯)
Shyamasree Ghosh，碩士，博士，PGDHE，PGDBI，自2009年以科學官員G的身份在印度奧里薩邦布巴內斯瓦爾的國家科學教育與研究所（NISER）生物科學學院（SBS）工作，該機構為孟買HBNI的運營中心。她於1998年畢業於享有盛譽的加爾各答總統學院，獲得動物學榮譽學位，並輔修化學和生理學，並在同年獲得印度政府頒發的國家獎學金。她於2000年在加爾各答大學完成生物技術的研究生學業，並在該校排名第二。
她在印度化學生物學研究所（IICB），CSIR，加爾各答獲得博士學位，並通過了印度政府人力資源發展部舉辦的國家資格考試。她於2005年在兒童急性淋巴母細胞白血病（ALL）領域的博士研究成果發表在多個國內外知名期刊上。隨後，她在班加羅爾的Manipal Health Systems和加爾各答的印度科學培育協會（IACS）擔任幹細胞科學家的博士後研究期間，專注於幹細胞和納米技術的研究。她在與班加羅爾大學附屬的研究生學院擔任生物技術系主任，直到2009年。
她作為單一作者和與其他合著者共同編寫和編輯了16本書籍。她的出版物在全球廣泛被引用，並因其學術努力在印度獲得多項獎項。
Sanjima Pal，碩士，博士，目前在加拿大麥吉爾大學健康中心研究所（RI-MUHC）擔任研究助理（員工科學家）。她負責一個專注於開發患者特異性、包含腫瘤微環境的器官芯片平台，以預測個體化的化學敏感性。此外，她還在研究改變的脂質代謝作為化學抗藥性驅動因素及其在胃食道癌中的潛在治療靶點。
她於2017年在印度奧里薩邦布巴內斯瓦爾的國家科學教育與研究所（NISER）生物科學學院獲得免疫化學生物學博士學位。2016年至2017年，她在加爾各答的薩哈核物理研究所的結晶學與分子生物學部門擔任研究助理。
她在密西根大學安娜堡的放射腫瘤學系完成了博士後研究訓練（2017-2020），在那裡她參與了一個藥物發現項目，專注於開發一類新型小分子，旨在通過干擾EGFR的二聚化來降解其功能。在麥吉爾大學的第二次博士後獎學金期間，她建立了一個微流體器官芯片平台，能夠模擬臨床條件以建模食道腺癌。
她目前是臨床試驗團隊的成員，參與分析接受圍手術期化學免疫療法的胃食道腺癌患者的免疫景觀。她的工作被廣泛引用，並在多個國內外會議上展示了她的研究。她因其學術成就獲得了多項獎項和獎學金。
