Vitamins and Neurodegeneration: Mechanisms and Therapeutic Insights
暫譯: 維他命與神經退化：機制與治療洞察

Nand Rai, Sachchida

Vitamins and Neurodegeneration: Mechanisms and Therapeutic Insights
  • 出版商: CRC
  • 出版日期: 2026-04-14
  • 售價: $6,410
  • 貴賓價: 9.5 折 $6,089
  • 語言: 英文
  • 頁數: 264
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 1041168500
  • ISBN-13: 9781041168508

    • 海外代購書籍(需單獨結帳)

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商品描述

This book examines the neurobiological impact of vitamins in the pathophysiology and prevention of neurodegenerative diseases, offering an integrative perspective on nutritional modulation of brain health. It explores the antioxidant, anti-inflammatory, and neurotrophic mechanisms of vitamins, alongside their pharmacokinetics, bioavailability, and blood-brain barrier transport. With a focus on age-associated deficiencies, impaired absorption, and cognitive decline, it highlights mechanistic links between micronutrient status and neuronal integrity. It also investigates synergistic interactions with cofactor minerals, polyunsaturated fatty acids, and polyphenols, as well as the influence of gut microbiota on vitamin-mediated neuroprotection. Specific emphasis is placed on the therapeutic implications of vitamins in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, and multiple sclerosis (MS).

Key Features:

  • Explores the neuroprotective and cognitive benefits of essential vitamins, including A, C, E, B complex, D, and K
  • Examines pharmacokinetics, bioavailability, and blood-brain barrier transport mechanisms relevant to vitamin efficacy
  • Analyzes the epidemiology of vitamin deficiency, aging-related malabsorption, and their link to cognitive impairment
  • Highlights nutrient-nutrient and vitamin-drug interactions in neurological health and therapy
  • Provides disease-specific insights into the role of vitamins in Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, and MS

This book is intended for researchers and students of neuroscience and nutritional sciences.

商品描述(中文翻譯)

這本書探討維他命在神經退行性疾病的病理生理學及預防中的神經生物學影響，提供了對於營養調節大腦健康的整合性觀點。它探討了維他命的抗氧化、抗發炎及神經營養機制，並分析其藥物動力學、生物可利用性及血腦屏障運輸。書中著重於與年齡相關的缺乏、吸收障礙及認知衰退，強調微量營養素狀態與神經元完整性之間的機制聯繫。它還研究了與輔助礦物質、多不飽和脂肪酸及多酚的協同作用，以及腸道微生物群對維他命介導的神經保護的影響。特別強調維他命在阿茲海默症、帕金森病、肌萎縮側索硬化症（ALS）、亨廷頓病及多發性硬化症（MS）中的治療意涵。

主要特點：
- 探討必需維他命的神經保護及認知益處，包括A、C、E、B群、D及K
- 檢視與維他命效能相關的藥物動力學、生物可利用性及血腦屏障運輸機制
- 分析維他命缺乏的流行病學、與年齡相關的吸收不良及其與認知障礙的聯繫
- 強調營養素之間及維他命與藥物在神經健康及治療中的相互作用
- 提供針對阿茲海默症、帕金森病、ALS、亨廷頓病及MS的維他命角色的疾病特定見解

這本書適合神經科學及營養科學的研究者和學生。

作者簡介

Sachchida Nand Rai is currently an assistant professor at the University Centre for Research & Development (UCRD), Chandigarh University, Mohali, Punjab, India. He earned his Ph.D. in Biochemistry from BHU in 2018. His research primarily focuses on the anti-Parkinsonian potential of medicinal plants such as Mucuna pruriens, Tinospora cordifolia, and Withania somnifera, as well as their bioactive constituents including ursolic acid, betulinic acid, and chlorogenic acid, particularly in toxin-induced Parkinsonian mouse models. Prior to his current role, Dr. Rai completed a 3-year postdoctoral fellowship at the Centre of Biotechnology, University of Allahabad, Prayagraj, from January 27, 2020, to January 26, 2023. He has made substantial contributions to neuroscience research, with numerous publications in high-impact journals. He serves as an academic editor and editorial board member for several reputed journals. Additionally, he is a member of the advisory board for Heliyon Neuroscience. His ongoing research investigates the neuroprotective effects of commonly used Indian medicinal plants in toxin-induced Parkinsonian models, aiming to uncover novel therapeutic strategies for neurodegenerative disorders.

作者簡介(中文翻譯)

Sachchida Nand Rai 目前是印度旁遮普邦莫哈里昌迪加爾大學研究與發展中心 (UCRD) 的助理教授。他於2018年在BHU獲得生物化學博士學位。他的研究主要集中在藥用植物如Mucuna pruriens、Tinospora cordifolia 和 Withania somnifera 的抗帕金森潛力，以及它們的生物活性成分，包括熊果酸、貝圖林酸和氯原酸，特別是在毒素誘導的帕金森小鼠模型中。在目前的職位之前，Rai博士於2020年1月27日至2023年1月26日在阿拉哈巴德大學生物技術中心完成了為期三年的博士後研究。他在神經科學研究方面做出了重要貢獻，並在高影響力的期刊上發表了多篇論文。他擔任多本知名期刊的學術編輯和編輯委員會成員。此外，他還是Heliyon Neuroscience的顧問委員會成員。他目前的研究調查了常用印度藥用植物在毒素誘導的帕金森模型中的神經保護作用，旨在發掘神經退行性疾病的新療法策略。

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