Neurodegenerative Diseases: Pathologies, Mechanisms, and Treatment Strategies
暫譯: 神經退行性疾病：病理、機制與治療策略

本書深入探討大腦健康、老化與神經退化的複雜性，探索遺傳、環境和生活方式因素在塑造大腦健康方面所扮演的多樣角色。它檢視這些因素對神經退化性疾病的發展和進程的貢獻。開篇章節介紹了血腦屏障的概念及其在維持大腦健康中的關鍵角色。書中還討論了隨著老化及各種神經退化性疾病，這一屏障如何受到損害，強調了理解疾病進程的重要性。本書回顧了特定的疾病，包括阿茲海默症（Alzheimer's Disease）和帕金森氏症（Parkinson's Disease），分析其潛在機制，並提出一系列藥物和非藥物治療方法，以及提供未來希望的新興療法。它還探討了其他神經退化性疾病，如肌萎縮側索硬化症（ALS）、亨廷頓舞蹈症（Huntington's Disease）和多發性硬化症，詳細說明導致神經退化的獨特途徑及最新的治療方法。各章節提供了有關大腦生物標記和診斷技術的見解，幫助早期檢測和診斷神經退化性疾病。最後，本書討論了患者和照顧者面臨的挑戰，並提供支持和應對的策略。本書是神經科學家和神經科醫生的重要資源。

Kakarla Ramakrishna is currently working as an Assistant Professor at the KL College of Pharmacy, part of the Koneru Lakshmaiah Education Foundation (KL University), Andhra Pradesh, India. He completed his Ph.D. from the Department of Pharmaceutical Engineering and Technology at IIT (BHU), Varanasi, UP, in 2022. Dr. Kakarla has published research and review articles in international journals and authored four chapters on neurological diseases and their management. Currently, he is working on platelets and thrombosis, neuronal damage to combat the ischemic stroke and its associated neuronal complications. Dr. Kakarla also working on identifying the natural bioactive compounds to combat Alzheimer's disease and diabetes associated brain damage through targeting oxidative stress, inflammation, and mitochondrial dysfunction.

Sachchida Nand Rai is a Research Associate (ICMR-RA) at Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi since 27th Jan 2023. Dr. Rai also completed his Ph.D from the Biochemistry Department (Institute of Science) from BHU. Before joining the BHU as Research Associate, he was post-doctoral fellow at Centre of Biotechnology, University of Allahabad, Prayagraj, India. He has published several research articles in high impact journals and has published 3 books. Dr. Rai serves as editorial board member in many reputed journals. He is investigating the neuroprotective activity of common Indian medicinal plants in toxin induced Parkinsonian mouse model. He is also member of the Indian Academy of Neurosciences, (India).

Santosh Kumar Singh is a Senior Scientist at Centre of Experimental Medicine and Surgery (CEMS), Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India. He completed his Ph.D. from the Botany Department (Institute of Science), BHU in 1998. He was a visiting scientist at Department of Photosynthesis, Institute of Physical Biology, University of South Bohemia, Czech Republic, in 2003. He has published more than 75 research articles in high impact factor journal and has published several books. Drug Discovery & Development, Microbial Biotechnology and Nanobiotechnology are some of his major areas of research. He is also Lifetime member of Mycological society of India, Lifetime member of Society of Biological Chemists, India, Member of the Society for Ethnopharmacology, Kolkata, India (SFE-INDIA). He also participated as resource person in Karyashala Training Course Under Accelerate Vigyan Scheme, SERB, DST. He was awarded with "National Award for "Outstanding Efforts in Science and Technology Communication through Innovative and Traditional methods (2021)" conferred by Department of Science and Technology, Ministry of Science and Technology, Government of India. He has received the order of academic excellence in publication (2020-2021), Institute of Medical Sciences, Banaras Hindu University, Varanasi.

Veer Singh is currently working as Young Scientist (DHR) at the Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India. He got PhD from the Indian Institute of Technology, Banaras Hindu University, Varanasi. He has published more than 40 research articles in international and national journals of high repute. His area of work involves environmental contamination & toxicity, the role of drinking water heavy metals contamination in visceral leishmaniasis (VL) & post-kala-azar dermal leishmaniasis (PKDL) development.

Kakarla Ramakrishna 目前擔任印度安得拉邦Koneru Lakshmaiah教育基金會（KL大學）KL藥學院的助理教授。他於2022年在印度瓦拉納西的印度理工學院（BHU）藥物工程與技術系獲得博士學位。Kakarla博士在國際期刊上發表了多篇研究和綜述文章，並撰寫了四章有關神經疾病及其管理的內容。目前，他正在研究血小板和血栓形成、神經損傷，以應對缺血性中風及其相關的神經併發症。Kakarla博士還致力於識別天然生物活性化合物，以通過針對氧化壓力、炎症和線粒體功能障礙來對抗阿茲海默症和與糖尿病相關的腦損傷。

Sachchida Nand Rai 自2023年1月27日起擔任印度瓦拉納西的班納拉斯印度大學（BHU）實驗醫學與外科中心的研究助理（ICMR-RA）。Rai博士也在BHU的生物化學系獲得博士學位。在加入BHU擔任研究助理之前，他曾在印度普拉亞格拉傑的阿拉哈巴德大學生物技術中心擔任博士後研究員。他在高影響力期刊上發表了多篇研究文章，並出版了三本書籍。Rai博士在許多知名期刊擔任編輯委員會成員。他正在研究常見印度藥用植物在毒素誘導的帕金森小鼠模型中的神經保護活性。他也是印度神經科學學會的成員。

Santosh Kumar Singh 是印度瓦拉納西班納拉斯印度大學醫學科學研究所實驗醫學與外科中心的高級科學家。他於1998年在BHU的植物學系獲得博士學位。2003年，他曾在捷克共和國南波希米亞大學的光合作用系擔任訪問科學家。他在高影響因子期刊上發表了超過75篇研究文章，並出版了多本書籍。藥物發現與開發、微生物生物技術和納米生物技術是他的主要研究領域之一。他還是印度真菌學會的終身會員、印度生物化學學會的終身會員、印度考爾卡塔民族藥理學會（SFE-INDIA）的成員。他還作為資源人員參加了SERB、DST的Accelerate Vigyan計劃下的Karyashala培訓課程。他獲得了印度科學與技術部頒發的「2021年科學與技術傳播創新與傳統方法的傑出努力國家獎」。他還獲得了班納拉斯印度大學醫學科學研究所的學術出版卓越獎（2020-2021）。

Veer Singh 目前在印度巴特那的Rajendra Memorial Research Institute of Medical Sciences生物化學系擔任青年科學家（DHR）。他在班納拉斯印度大學的印度理工學院獲得博士學位。他在國際和國內知名期刊上發表了超過40篇研究文章。他的研究領域涉及環境污染與毒性、飲用水重金屬污染在內臟利什曼病（VL）和後卡拉阿札利皮膚利什曼病（PKDL）發展中的作用。