Insight on Genotoxicity
暫譯: 基因毒性洞察

Shukla, Shiv Shankar, Pandey, Ravindra Kumar, Gidwani, Bina

Insight on Genotoxicity
  • 出版商: CRC
  • 出版日期: 2020-10-15
  • 售價: $5,230
  • 貴賓價: 9.5 折 $4,969
  • 語言: 英文
  • 頁數: 152
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 0367473372
  • ISBN-13: 9780367473372

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint.

Salient Features

  • Presents methods, standard protocols, and guidelines for genotoxicity testing

  • Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development

  • Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects

  • Discusses advancement in the high-throughput approaches for genotoxicity testing

  • Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

商品描述(中文翻譯)

遺傳毒理學被視為一個重要的評估工具，因為人工化學物質對基因有影響。基因毒性洞察討論了基因毒性的測試、機制、預測和生物指標，並考慮到最近在奈米工程顆粒方面的進展。DNA損傷的相關性也被詳細討論，並考慮到ICH指導方針對基因毒性測試的影響，這對於藥物發現的創新和開發至關重要。文中提及了植物藥中基因毒性評估的觀點回顧，以及對基因毒性的預防的簡要看法。

主要特點




  • 提供基因毒性測試的方法、標準協議和指導方針




  • 檢視ICH指導方針對基因毒性測試的影響，這是藥物發現和開發的法規要求




  • 定義有關in vivo基因毒性測試進展的適當策略，並列出進展和前景




  • 討論基因毒性測試的高通量方法的進展




  • 詳細說明基因毒性的計算預測，考慮到致突變性、造成的染色體損傷以及在藥物開發中的計算預測策略


作者簡介

Dr. Shiv Shankar Shukla obtained his Ph.D from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University. Presently he is Professor at Columbia Institute of Pharmacy. He has more than 65 publications to his credit in reputed journals. He has authored two books titled "Inflammation: Natural Resources and Its Applications" and "Finger Printing Analysis and Quality Control Methods of Herbal Medicines". He has written three book chapters published in reputed Publishing House.

Dr. Ravindra Pandey gained his Ph.D from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University. Presently he is Professor at Columbia Institute of Pharmacy. He has more than 65 publications to his credit in reputed journals. He has authored two books titled "Inflammation: Natural Resources and Its Applications" and "Finger Printing Analysis and Quality Control Methods of Herbal Medicines". He has written three book chapters in reputed Publishing House.

Dr. Bina Gidwani obtained her Ph. D from University Institute of Pharmacy, Pt. Ravishankar Shukla University. Presently, she is serving as Associate Professor at Columbia Institute of Pharmacy. She has more than 55 publications to her credit. She has authored one book and two book chapters in reputed Publishing House.

Mr. Gunjan Kalyani is Post Graduate from Chhattisgarh Swami Vivekanada Technical University (CSVTU), Bhilai, Chhattisgarh. Presently, he is Assistant Professor at Columbia Institute of Pharmacy. He has 26 publications to his credit in various journals of International and National repute.

作者簡介(中文翻譯)

Dr. Shiv Shankar Shukla 於 Pt. Ravi Shankar Shukla University 的大學藥學院獲得博士學位。目前他是 Columbia Institute of Pharmacy 的教授。他在知名期刊上發表了超過 65 篇論文。他著有兩本書，分別為 'Inflammation: Natural Resources and Its Applications' 和 'Finger Printing Analysis and Quality Control Methods of Herbal Medicines'。他還在知名出版社撰寫了三個書章節。

Dr. Ravindra Pandey 於 Pt. Ravi Shankar Shukla University 的大學藥學院獲得博士學位。目前他是 Columbia Institute of Pharmacy 的教授。他在知名期刊上發表了超過 65 篇論文。他著有兩本書，分別為 'Inflammation: Natural Resources and Its Applications' 和 'Finger Printing Analysis and Quality Control Methods of Herbal Medicines'。他還在知名出版社撰寫了三個書章節。

Dr. Bina Gidwani 於 Pt. Ravishankar Shukla University 的大學藥學院獲得博士學位。目前，她擔任 Columbia Institute of Pharmacy 的副教授。她發表了超過 55 篇論文。她著有一本書和兩個書章節，均在知名出版社出版。

Mr. Gunjan Kalyani 於 Chhattisgarh Swami Vivekanada Technical University (CSVTU) 獲得碩士學位，目前是 Columbia Institute of Pharmacy 的助理教授。他在各類國際和國內知名期刊上發表了 26 篇論文。

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