Cancer Stem Cells: Basic Concept and Therapeutic Implications

Islam, Farhadul, Lam, Alfred K.

Cancer Stem Cells: Basic Concept and Therapeutic Implications
  • 出版商: Springer
  • 出版日期: 2024-07-27
  • 售價: $7,580
  • 貴賓價: 9.5 折 $7,201
  • 語言: 英文
  • 頁數: 372
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 9819931878
  • ISBN-13: 9789819931873

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

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商品描述(中文翻譯)

本書全面回顧了癌症幹細胞（CSCs）在癌症發生、進展及對抗癌療法抵抗中的角色。初始章節探討了檢測、分離和特徵化CSCs的方法和程序。書中還介紹了多種促進癌症發生和腫瘤生成的表觀遺傳途徑，特別是關於CSCs的維持和存活。它還探討了CSCs代謝的角色以及CSCs在癌症生物學中代謝可塑性的機制。此外，本書還呈現了CSCs對腫瘤異質性起源及治療反應異質性的影響。最後，本書強調了針對CSCs的不同免疫療法，這些療法有潛力顯著改善癌症治療結果。本書為科學家和臨床醫生提供了一個廣泛的框架，介紹了癌症幹細胞生物學的最新知識，並突顯了其治療意涵。

作者簡介

Dr Farhadul Islam is an Associate Professor at the Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh. His research interests are focused on cancer biology, cancer genetics, epigenetics, drug development, and identification of the molecular markers in various cancers. He has more than 10 years of teaching and research experience in Cell Biology, Molecular Biology, Biochemistry, Molecular Oncology, Cancer Pathology, Drug Development and Discovery. He is serving as an Associate Editor of BMC Cancer, Editorial Broad Member of Anticancer Agents and Medicinal Chemistry and Guest Editor of Frontiers in Endocrinology and Frontiers in Oncology. He has been awarded several prestigious awards, including Academic Excellence Award and Chancellor's medal, Early Career Researcher award from Griffith University, Australia. He was also awarded Dean's Award from Faculty of Science, University of Rajshahi, Bangladesh for his outstanding research performance. He has published more than 70 research articles in peer-reviewed international journals and has authored or co-authored several book chapters and book on cancer pathogenesis. He also is a member of many national and international scientific societies and organizations.

Professor Alfred Lam is a senior visiting pathologist and Professor of Pathology in Griffith University, Australia since 2004. His research focuses on diagnosis, molecular biology, cancer stem cell and treatment of cancers, in particular endocrine, gastrointestinal as well as head/neck tumours. He has published more than 450 referred journal articles, contributed more than 70 chapters in books on cancers, including chapters in World Health Organization books on tumours in Endocrine system, Head & Neck, and Digestive system. He has also edited 3 books in topics on molecular pathology of cancers as well as an editor of Fifth edition of World Health Organization book on tumours of the Digestive system. In addition, he contributed to more than 10 cancer structured report for use in Australia and globally and was nominated to Chair the development of the Dataset for the reporting of oesophageal cancer by International Collaboration on Cancer Reporting (ICCR).


作者簡介(中文翻譯)

Dr. Farhadul Islam 是孟加拉國拉傑沙希大學生物化學與分子生物學系的副教授。他的研究興趣集中在癌症生物學、癌症遺傳學、表觀遺傳學、藥物開發以及各種癌症的分子標記識別上。他在細胞生物學、分子生物學、生物化學、分子腫瘤學、癌症病理學、藥物開發與發現方面擁有超過10年的教學和研究經驗。他擔任《BMC Cancer》的副編輯、《抗癌劑與藥物化學》的編輯委員會成員，以及《內分泌學前沿》和《腫瘤學前沿》的客座編輯。他獲得了多項著名獎項，包括學術卓越獎和校長獎章、來自澳大利亞格里菲斯大學的早期職業研究者獎。他還因其卓越的研究表現獲得了孟加拉國拉傑沙希大學科學院的院長獎。他在同行評審的國際期刊上發表了超過70篇研究文章，並撰寫或共同撰寫了幾本有關癌症發病機制的書籍章節。他還是許多國內外科學學會和組織的成員。

阿爾弗雷德·藍教授自2004年以來擔任澳大利亞格里菲斯大學的高級訪問病理學家和病理學教授。他的研究專注於診斷、分子生物學、癌症幹細胞及癌症治療，特別是內分泌系統、消化系統以及頭頸部腫瘤的研究。他已發表超過450篇經審核的期刊文章，並在有關癌症的書籍中貢獻了超過70個章節，包括世界衛生組織有關內分泌系統、頭頸部和消化系統腫瘤的書籍章節。他還編輯了3本有關癌症分子病理學的書籍，以及世界衛生組織消化系統腫瘤第五版書籍的編輯。此外，他為澳大利亞及全球使用的癌症結構報告貢獻了超過10份，並被提名為國際癌症報告合作組織（ICCR）食道癌報告數據集開發的主席。

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