The Molecular Immunology of Complex Carbohydrates - 4: The Expanding Landscape of Glycoscience
暫譯: 複雜碳水化合物的分子免疫學 - 4: 糖科學的擴展領域

本書涵蓋了過去十年來糖科學的擴展領域，延續了早期名為《複雜碳水化合物的分子免疫學 1、2 和 3》的書籍。其目的是提供糖科學領域的系統性和全面性回顧。除了糖類在免疫系統中的多樣角色外，本卷還擴展了其範疇，包括 (i) 涉及人體多個系統的人類糖科學——最顯著的是神經系統，影響生理過程如神經元軸突生成以及病理狀況如阿茲海默症，(ii) 微生物糖科學，以及 (iii) 環境糖科學。

此外，本書還特別關注糖科學在生物技術和化學技術中的當前及新興應用。

本書由 36 章組成，作者包括 89 位國際知名專家，以及一位為已故母親的校稿工作而作的作者，提供了對糖類生物合成和結構的廣泛而深入的探索，並延伸至其在各種人類生物系統和微生物生理中的功能意義。它詳細闡述了複雜的生物互動——不僅是細胞間的識別和通信，還包括宿主與微生物、人類與食物或花粉之間的動態關係，甚至是食物與花粉之間的交叉反應。本書突顯了現代生物技術和化學創新在基於糖類和糖結合蛋白（凝集素）合成及應用中的重要性，這些應用涉及生理和病理疾病的檢測、診斷、預防和治療。書中還詳細介紹了基於糖類和凝集素的疫苗開發及生物醫學研究的前沿範例。

本書配有大量解釋性插圖，並廣泛參考了基礎和近期文獻，成為生命科學和醫學領域的學生、早期職業科學家、研究人員、臨床醫生和專家的寶貴資源。

Dr. Albert M. Wu obtained his Ph.D degree with W. Pigman, who is one of the pioneers in glycoproteins, at New York Medical College; and had his postdoctoral training at E.A. Kabat's Lab for quantitative immunochemistry, Columbia University Medical Center, New York. He joined as a faculty position at Texas A&M University in 1982; promoted as a full professor at Chang-Gung University since 1989; and as Emeritus Professor after 2011. Dr. Wu published over 120 glycoprotein and polyvalent glycotopes related papers. He is the chief editor for three volumes of Molecular Immunology of COMPLEX Carbohydrates 1 to 3 in Adv. Exp. Med. Biol. 228, 451, 705 (Springer Publisher). His major interests are (i) Glycan purification and characterization; (ii) recognition factors of glycans; (iii) combining sites of lectins and antibodies. He received many Outstanding Research Awards from government agents in Taiwan and U.S.A.

Alessandro Prinetti received his Ph.D. in Biochemistry in 1997 from the University of Milan, Italy under the guidance of Professor Guido Tettamanti, and the laboratory of S. Hakomori at the Dept. of Pathobiology, Pacific Northwest Research Institute, University of Washington (Seattle, WA, USA). In 1997-98 he was Senior Fellow at the Department of Pathobiology, University of Washington, Seattle, USA under the supervision of late Professor Sen-itiroh Hakomori. He is currently Full Professor of Biochemistry at the Department of Medical Biotechnology and Translational Medicine, School of Medicine, University of Milan.

In the early years of his scientific activity, he contributed to elucidate glycosphingolipid metabolic pathways in the nervous system, and in particular to define the metabolic mechanisms responsible for the generation of bioactive sphingolipids. Later on, he contributed to define the concept of lipid rafts. In particular, his research highlighted the importance of sphingolipids in modulating the generation of signals at the plasma membrane by either determining the dynamic properties of specialized membrane signaling platforms, or affecting the activity of plasma membrane signaling complexes via specific sphingolipid-protein interactions. His achievements shed a new light on the role of sphingolipids in the physiopathology of nervous system and in tumor cell biology. In particular, he studied sphingolipid patterns, metabolism and function related to neuronal differentiation and neurodegeneration, myelin formation and repair, neoplastic transformation, tumor cell adhesion and invasiveness. His current main research projects deal with the role of sphingolipids in myelin formation and repair of damaged myelin. He is actively involved in the activities of international scientific societies, has been the President of the European Society for Neurochemistry (2015-17) and is currently Treasurer of the International Society for Neurochemistry (2021-25).

Nongluk Sriwilaijaroen received her B.Sc. degree in 1996 in Biotechnology, and her M.Sc. and Ph.D. degrees in 1999 and in 2004, respectively, in Biochemistry from Mahidol University. In 2002-2003, she was a visiting research student at the Medical Research Service, Department of Veteran's Affairs Medical Center, Portland, Oregon, USA. Currently, she is an associate professor in the Department of Preclinical Sciences, Faculty of Medicine, Thammasat University. In 2007-2010, she was a postdoctoral fellow under the direction of Prof. Dr. Yasuo Suzuki in College of Life and Health Sciences, Chubu University, Japan. In 2010-2019, she was a visiting researcher and a visiting professor in Chubu University, Japan. Since 2020, she has been a visiting researcher in the University of Shizuoka, Japan. She was a member of The Japanese Society of Carbohydrate Research and The Japanese Society of Pathology. Her research of interests includes biochemical and molecular biology of sialoside-recognizing viruses and their host cells in particular of adaptation and evolution of receptor-binding spike glycoproteins and receptor-destroying spike enzymes, and discovery and development of drugs against sialoside-recognizing viruses.

Yasuo Suzuki received his Ph.D. in 1974 from Department of Biochemistry, Shizuoka College of Pharmacy under the supervision of Prof. Dr. Makoto Matsumoto. He continued his work as a research associate and contributed works in the structures and functions of the complex lipids, especially sialoglycosphingolipids, and sialoglycoproteins in cell membranes. He found "new ganglioside molecules carrying different molecular species of sialic acid, which bind to human influenza viruses" and published it as his first influenza work in J. Biol. Chem. in 1985. He then developed a new scientific field, "glycovirology". In 1989-2006, he was a full professor at University of Shizuoka School of Pharmaceutical Sciences. In 1996-2002, he was a dean of graduate school and school of pharmaceutical Sciences of the University of Shizuoka. In 2006, he moved to Chubu University as a full professor. In 2008-2013, he became a director of Institute of Life and Health Science Hills of Chubu university. In 2013-2021, he was a visiting professor at Chubu University. In addition to being a professor emeritus of the University of Shizuoka since 2003, he has become a visiting professor at the University of Shizuoka since 2020. His work focuses on sialoglycovirology and antiviral drug discovery. He received The Pharmaceutical Society of Japan Award 2004 and Chunichi Cultural Award 2004. He served the international grant reviewer for "Top grants earth and life sciences", Netherlands Organization for Scientific Research, Netherlands (2012).

吳阿伯特博士於紐約醫學院獲得其博士學位，指導教授為W. Pigman，他是糖蛋白領域的先驅之一；並在哥倫比亞大學醫學中心E.A. Kabat實驗室接受定量免疫化學的博士後訓練。他於1982年加入德州農工大學擔任教職；自1989年起晉升為長庚大學的正教授；並於2011年後成為名譽教授。吳博士發表了超過120篇與糖蛋白和多價糖基相關的論文。他是《複雜碳水化合物的分子免疫學》第一至第三卷的主編，該書發表於Adv. Exp. Med. Biol. 228, 451, 705（Springer出版社）。他的主要研究興趣包括：(i) 糖類的純化與特徵分析；(ii) 糖類的識別因子；(iii) 醣蛋白和抗體的結合位點。他曾獲得來自台灣和美國政府機構的多項傑出研究獎。

亞歷山德羅·普里內提於1997年在意大利米蘭大學獲得生物化學博士學位，指導教授為Guido Tettamanti，並在美國華盛頓大學太平洋西北研究所的病理生物學系S. Hakomori實驗室進行研究。1997至1998年，他在美國華盛頓大學病理生物學系擔任高級研究員，指導教授為已故的Sen-itiroh Hakomori教授。目前，他是米蘭大學醫學院醫療生物技術與轉化醫學系的正教授。

在他科學活動的早期，他對神經系統中的糖鞘脂代謝途徑進行了闡明，特別是定義了生成生物活性鞘脂的代謝機制。隨後，他對脂質筏的概念進行了定義。特別是，他的研究突顯了鞘脂在調節細胞膜信號生成中的重要性，無論是通過決定專門膜信號平台的動態特性，還是通過特定的鞘脂-蛋白質相互作用影響細胞膜信號複合體的活性。他的成就為鞘脂在神經系統生理病理學和腫瘤細胞生物學中的角色提供了新的見解。特別是，他研究了與神經分化和神經退行性變、髓鞘形成和修復、腫瘤轉化、腫瘤細胞黏附和侵襲性相關的鞘脂模式、代謝和功能。他目前的主要研究項目涉及鞘脂在髓鞘形成和受損髓鞘修復中的角色。他積極參與國際科學社會的活動，曾擔任歐洲神經化學學會會長（2015-2017），目前是國際神經化學學會的財務主管（2021-2025）。

斯里瓦拉伊詹農於1996年獲得生物技術學士學位，並於1999年和2004年分別獲得生物化學碩士和博士學位，均來自馬希多大學。2002至2003年，她在美國俄勒岡州波特蘭的退伍軍人事務醫療中心醫學研究服務部擔任訪問研究生。目前，她是泰國法政大學醫學院臨床前科學系的副教授。2007至2010年，她在日本中部大學生命與健康科學學院的鈴木康夫教授指導下擔任博士後研究員。2010至2019年，她在日本中部大學擔任訪問研究員和訪問教授。自2020年以來，她在日本靜岡大學擔任訪問研究員。她是日本碳水化合物研究學會和日本病理學會的成員。她的研究興趣包括識別唾液酸的病毒及其宿主細胞的生化和分子生物學，特別是受體結合刺突糖蛋白和破壞受體的刺突酶的適應和演化，以及針對識別唾液酸病毒的藥物的發現和開發。

鈴木康夫於1974年在靜岡藥科大學生物化學系獲得博士學位，指導教授為松本誠博士。他繼續擔任研究助理，並在複雜脂質的結構和功能方面做出貢獻，特別是細胞膜中的唾液酸糖鞘脂和唾液酸糖蛋白。他發現了“攜帶不同分子物種的唾液酸的新神經節苷脂分子，這些分子與人類流感病毒結合”，並於1985年在《生物化學雜誌》上發表了他的第一篇流感研究。隨後，他開創了一個新的科學領域——“糖病毒學”。1989至2006年，他在靜岡大學藥學院擔任正教授。1996至2002年，他擔任靜岡大學研究生院和藥學院的院長。2006年，他轉至中部大學擔任正教授。2008至2013年，他成為中部大學生命與健康科學研究所的主任。2013至2021年，他在中部大學擔任訪問教授。自2003年以來，他成為靜岡大學的名譽教授，自2020年以來成為靜岡大學的訪問教授。他的研究專注於唾液酸糖病毒學和抗病毒藥物的發現。他於2004年獲得日本藥學會獎和2004年中日文化獎。他曾擔任荷蘭科學研究組織的“地球與生命科學頂級資助”國際評審（2012年）。