Systems Biology II
Barciszewski, Jan
- 出版商: Springer
- 出版日期: 2024-11-01
- 售價: $7,700
- 貴賓價: 9.5 折 $7,315
- 語言: 英文
- 頁數: 372
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031621778
- ISBN-13: 9783031621772
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商品描述
Modern biology is moving away from reductionist approaches towards holistic studies that encompass whole genomes, transcriptomes, proteomes, and metabolomes. Systems biology is an approach to studying complex biological systems by looking at many biomolecules in a comprehensive way. The aim is to gain a thorough understanding of the biological functions of different classes of molecules and their interactions.
Systems Biology II is an up-to-date and comprehensive guide to the latest developments in systems biology, with a particular focus on RNA-based technologies. This book is the second volume in the RNA Technologies series dedicated to this topic. It presents cutting-edge approaches and tools for modelling and analyzing complex biological systems at different levels, from molecular interactions to cellular networks and beyond.
With contributions from leading experts in the field, the book covers a wide range of topics, including gene regulatory networks, epigenetics, synthetic biology, omics data analysis, network inference, and more. It explores applications in various areas of the life sciences and biomedicine, such as vaccine development, cancer research, transplantation research and pathogenic processes.
This volume is an essential resource for scientists and students working in systems biology, bioinformatics, synthetic biology, and related fields, as well as anyone interested in the latest advances in RNA technologies and their applications in biology and medicine.
商品描述(中文翻譯)
現代生物學正從還原主義的方法轉向綜合研究，包括整個基因組、轉錄組、蛋白質組和代謝組。系統生物學是一種綜合性研究複雜生物系統的方法，通過全面觀察許多生物分子來進行。其目的是深入了解不同類型分子的生物功能及其相互作用。
《系統生物學 II》是一本關於系統生物學最新發展的全面指南，特別關注基於RNA的技術。這本書是專門為這一主題而設的《RNA技術系列》的第二卷。它介紹了在不同層次上對複雜生物系統進行建模和分析的尖端方法和工具，從分子相互作用到細胞網絡等。
本書由該領域的領先專家貢獻，涵蓋了廣泛的主題，包括基因調控網絡、表觀遺傳學、合成生物學、組學數據分析、網絡推斷等。它探討了在生命科學和生物醫學的各個領域中的應用，如疫苗開發、癌症研究、移植研究和致病過程。
本卷是系統生物學、生物信息學、合成生物學和相關領域的科學家和學生的重要資源，以及對RNA技術在生物學和醫學中的最新進展及其應用感興趣的任何人。
作者簡介
Jan Barciszewski is Professor at Adam Mickiewicz University (AMU) in Poznań, Poland, and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland, where he has worked since 1974. He studied organic chemistry at the AMU. During his Ph.D. studies, he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine-specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s, he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents.
作者簡介(中文翻譯)
Jan Barciszewski是波蘭波茲南亞當·密克維茨大學(AMU)和波蘭科學院生物有機化學研究所的教授，自1974年以來一直在該所工作。他在AMU學習有機化學。在他的博士研究期間，他研究了植物苯丙氨酸特異性轉移核糖核酸(tRNA)的修飾碱基和核苷酸序列的結構和功能，包括細胞激素。隨後，他因對植物tRNA和氨酰-tRNA合成酶的性質研究而獲得博士學位。在1990年代，他開始研究腦腫瘤的診斷和治療。他開發了一種基於催化RNA的植物粒線體轉化新方法，目前還參與研究一種新型的催化RNA（對映異構核酶），用於體內高效的RNA靶點切割，以及尋找新的抗衰老劑。
