Aging: How Science Works
Carlberg, Carsten, Ulven, Stine M., Velleuer, Eunike
- 出版商: Springer
- 出版日期: 2024-08-15
- 售價: $2,840
- 貴賓價: 9.5 折 $2,698
- 語言: 英文
- 頁數: 175
- 裝訂: Quality Paper - also called trade paper
- ISBN: 3031612566
- ISBN-13: 9783031612565
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商品描述
Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get.
The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells.
We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer.
We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says "Teach us to number our days, that we may get a heart of wisdom." It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have.
商品描述(中文翻譯)
老化是一個關乎我們所有人的話題，因為沒有人能逃脫它。分子和細胞過程存在於我們身體的數十億個細胞中。其中一些細胞，如免疫細胞和紅血球，只能存活幾天到幾週，並且不斷被骨髓中產生的細胞取代。相反，有些細胞，如神經元和記憶淋巴細胞，隨著我們的年齡增長而變老。
老化的過程限制了我們的最大壽命，對於人類而言，這個壽命是120歲。然而，只有極少數人達到了這個年齡。他們的生活與數十年前去世的其他人有何不同？是只有沒有威脅生命的疾病並且有更健康的生活方式嗎？還是這是內在於我們的基因組或表觀基因組？在這本書中，我們試圖從進化、基因組、我們不同組織和細胞類型的表觀基因組以及我們細胞的功能的角度回答這些問題。
我們應該試著詳細了解自己，以及在全球範圍內。基礎生物學解釋了細胞機制，如生長、分化和細胞死亡，這使得整個生命成為可能。每個（人類）有機體代表著數百種不同細胞類型之間的複雜相互作用，形成具有特殊任務的獨特組織和器官。這些過程需要在發育、維持和老化期間高度協調。研究老化的細胞和分子基礎是最迷人的領域之一，但也是一個巨大的挑戰。然而，通過研究正常機制的故障導致不同疾病（如早衰綜合徵和癌症），研究已經在闡明生物過程方面取得了最大的進展。
我們將從理解人類基因組與進化原則的關係開始這本書。然後，我們將解釋基因調控和表觀遺傳學的基礎，即轉錄因子和染色質的相互作用。接下來，我們將轉向老化的細胞機制，然後討論營養和免疫對老化過程的影響。接下來，我們將探討老化與所謂的與老化相關的常見疾病（如2型糖尿病、動脈粥樣硬化、癌症和阿茲海默症）的關係。我們是否因為老化而患上這些疾病，還是因為患上這些疾病而老化？本書將以我們如何減緩老化過程以實現健康老化作為結尾。簡而言之，健康老化不是一個選擇，而是一個必須。一首古詩說：“教我們數算自己的日子，好讓我們得到智慧的心。”這取決於我們每個人，是一個每天都要做出的決定，活出健康的生活方式，並意識到我們所有人都擁有的獨特禮物。
作者簡介
Carsten Carlberg graduated in 1989 with a Ph.D. in biochemistry at the Free University Berlin (Germany). After positions as Postdoc at Roche (Basel, Switzerland), Group Leader at the University of Geneva (Switzerland) and Docent at the University of Düsseldorf (Germany), he is since 2000 Full Professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). Since 2022, Prof. Carlberg is ERA Chair for nutrigenomics at the Polish Academy of Science. His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present, Prof. Carlberg's projects focus on epigenome-wide effects of vitamin D on the human immune system in the context of cancer.
Stine Marie Ulven graduated in 2000 with a Ph.D. in nutrition at the University of Oslo (Norway). Since 2015 she is professor at the Department of Nutrition, Institute of Basic Medical Sciences at the University of Oslo (Norway). The main research interests of Prof. Ulven are human dietary intervention studies and diet-gene interactions with particular focus on the role of dietary fat in prevention of chronic diseases.
Eunike Velleuer graduated in 2006 as M.D. at the University of Düsseldorf (Germany) and specialized in 2016 in pediatric hemato-oncology. At present, she serves as Senior Physician at the Helios Children's Clinic Krefeld as well as Research Associate at the University of Düsseldorf. Her special clinical focus is the cancer predisposition syndrome Fanconi anemia. Herein, her research interest is early detection and prevention of oral squamous cell carcinoma. Furthermore, Dr. Velleuer is interested in increasing patients' resilience and finding alternative ways for long-lasting empowerment.
作者簡介(中文翻譯)
Carsten Carlberg於1989年在德國柏林自由大學獲得生物化學博士學位。在Roche（瑞士巴塞爾）擔任博士後研究員、日內瓦大學（瑞士）擔任研究小組負責人以及杜塞爾多夫大學（德國）擔任Docent之後，他自2000年起擔任芬蘭東部大學（芬蘭庫奧皮奧）的生物化學教授。自2022年起，Carlberg教授擔任波蘭科學院的營養基因組學ERA主席。他的研究主要集中在核激素對基因調控機制的影響，尤其是維生素D。目前，Carlberg教授的項目主要關注維生素D對人類免疫系統在癌症背景下的表觀基因組效應。
Stine Marie Ulven於2000年在挪威奧斯陸大學獲得營養學博士學位。自2015年起，她擔任奧斯陸大學基礎醫學科學研究所營養學系的教授。Ulven教授的主要研究興趣是人類膳食干預研究和飲食基因相互作用，尤其關注膳食脂肪在慢性疾病預防中的作用。
Eunike Velleuer於2006年在德國杜塞爾多夫大學獲得醫學博士學位，並於2016年專攻小兒血液腫瘤學。目前，她擔任赫利歐斯兒童診所克雷費爾德的高級醫師，並在杜塞爾多夫大學擔任研究助理。她的臨床專長是癌症易感綜合徵Fanconi貧血，研究興趣是口腔鱗狀細胞癌的早期檢測和預防。此外，Velleuer博士對提高患者的韌性和尋找長期賦能的替代方法也感興趣。
