商品描述
This book provides an overview of the metabolism of dietary compounds by the intestinal microbiota, and on the consequences of such metabolic activity on host metabolism and physiological functions; both in intestinal and peripheral tissues.
Over the last years, our understanding of the causal links between microbiota metabolic activity towards dietary and endogenous substrates and human health status has evolved extensively. In this context, the book starts with a comprehensive introduction devoted to the physiological and metabolic functions of the intestinal epithelium, followed by a part dedicated to the way intestine offers board and lodging for microbes being on a short- or long-term stay. The next chapters focus on the utilization of the available substrates from diet by the intestinal bacteria to produce numerous bacterial metabolites, and on the impact of such microbial activity, in the first place for communication between microbes, and for communication between microbes and lodging host. As will be detailed, this latter process of interkingdom communication leads to either beneficial or deleterious effects on intestinal physiology and metabolism. Special attention is given to selected pathophysiological processes namely chronic intestinal inflammation, colorectal carcinogenesis, and diarrhea. Then, the effects of modifications of bacterial metabolites and other bioactive compounds by the host after intestinal absorption, and consequences for peripheral tissue functions are presented.
Summarizing the state of the art on what is known about the metabolic crosstalk between gut microbiota and human metabolism, as well as perspectives for further experimental and clinical research, this book provides a useful resource for researchers, professionals, and students with a background in biology, and/or nutrition, medicine, pharmacology, and for those which are involved in the agriculture and food production. By explaining technical terms all along the text, this book should be understandable also for interested non-specialists.
商品描述(中文翻譯)
本書概述了腸道微生物對飲食化合物的代謝以及這種代謝活動對宿主代謝和生理功能的影響，無論是在腸道還是周邊組織中。
近年來，我們對微生物代謝活動與飲食和內源性底物之間的因果關係對人類健康狀態的理解已經大大發展。在這個背景下，本書首先全面介紹了腸道上皮的生理和代謝功能，然後專門介紹了腸道如何為短期或長期停留的微生物提供住宿和食物。接下來的章節重點介紹了腸道細菌利用飲食中的可利用底物產生大量細菌代謝物，以及這種微生物活動對微生物之間以及微生物與宿主之間的通訊的影響。正如將詳細介紹的那樣，這種跨界通訊過程對腸道生理和代謝產生有益或有害的影響。特別關注選定的病理生理過程，包括慢性腸道炎症、結腸癌發生和腹瀉。然後，介紹了腸道吸收後宿主對細菌代謝物和其他生物活性化合物進行修改的影響，以及對周邊組織功能的影響。
總結腸道微生物與人體代謝之間的代謝相互作用的最新研究成果，以及進一步實驗和臨床研究的展望，本書為具有生物學、營養學、醫學、藥理學背景的研究人員、專業人士和學生提供了有用的資源，同時也適用於從事農業和食品生產的人士。通過在整個文本中解釋技術術語，本書也可讓非專業人士理解。
作者簡介
François Blachier worked as Research Director at the National Institute for Agriculture, Alimentation and Environment (INRAe). He was deputy director of the Nutrition Physiology and Alimentary Behavior laboratory, which is one of the research units belonging to the Université Paris-Saclay/AgroParisTech/INRAe consortium. After working as research assistant at McGill University in Montréal (Canada), at Brussels Free University (Belgium), and at the Institute of Animal Physiology and Genetics in Cambridge (UK), he received his PhD in Cellular and Molecular Pharmacology from Université Pierre and Marie Curie (Paris, France), and then joined INRAe. Presently, his main research interest is related to the metabolic crosstalk between the bacteria living in our gut and ourselves, and on the consequences of such bacterial metabolic activity towards dietary compounds on the intestinal metabolism and physiology in different situations including healthy state, and mucosal healing after an inflammatory episode. He has published over 170 articles (source PubMed) that have been cited over 9 000 times (Research Gate). He has worked as an expert for numerous international scientific organizations and received numerous invitations to give lectures in Europe, USA, Canada, China, Japan, Vietnam, Korea, Brazil, Chile, Egypt, and Togo. François Blachier worked as associate editor for the journals Amino Acids, and as member of the editorial board of the journals Microorganisms, Nutrition Research and Practice, Animal Nutrition and Journal of Animal Science and Biotechnology; and as academic editor for PLoS ONE.
作者簡介(中文翻譯)
François Blachier 曾在國家農業、食品和環境研究所（INRAe）擔任研究主任。他曾擔任營養生理學和飲食行為實驗室的副主任，該實驗室是巴黎-索克萊大學/AgroParisTech/INRAe聯盟的研究單位之一。在此之前，他曾在加拿大蒙特利爾的麥吉爾大學、比利時布魯塞爾自由大學和英國劍橋的動物生理學和遺傳學研究所擔任研究助理，並在法國巴黎皮埃爾和瑪麗居里大學獲得細胞和分子藥理學博士學位後加入INRAe。目前，他的主要研究興趣是腸道內居住的細菌與我們自身之間的代謝相互作用，以及這些細菌代謝活動對腸道代謝和生理的影響，包括健康狀態和炎症後的黏膜癒合等不同情況。他在PubMed上發表了超過170篇文章，被引用超過9,000次（Research Gate）。他曾擔任多個國際科學組織的專家，並獲得了在歐洲、美國、加拿大、中國、日本、越南、韓國、巴西、智利、埃及和多哥等地發表演講的邀請。François Blachier曾擔任《氨基酸》期刊的副編輯，並擔任《微生物》、《營養研究與實踐》、《動物營養學》和《動物科學與生物技術學》期刊的編輯委員會成員；並擔任PLoS ONE的學術編輯。
