The Metagenomics Revolution: Unlocking the Potential Microbial Communities in Diagnostics and Beyond
暫譯: 宏基因組革命：解鎖微生物群落在診斷及其他領域的潛力

《宏基因組革命：解鎖診斷及其他領域中的微生物社群潛力》是一本全面的資源，涵蓋了宏基因組學的基本原則、方法論和前沿進展。它彌補了理論理解與實際應用之間的差距，使其成為研究人員、臨床醫生、工程師和行業專業人士的重要指南。通過整合微生物學、生物資訊學、生物技術和臨床診斷的概念，本書提供了一種多學科的方法來進行宏基因組分析及其在現實世界中的應用。主要目的是使讀者全面了解宏基因組學，從樣本收集和測序技術到計算工具和數據解釋。本書探討了如何利用宏基因組測序進行多種應用，包括臨床診斷、抗微生物抗藥性監測、環境監測、農業微生物組研究和工業生物技術。它提供了一個分析複雜微生物數據集的結構化框架，強調生物資訊學流程、多組學整合和人工智慧驅動的微生物分析中的最佳實踐。

Dr. Vivek Kumar is a postdoctoral researcher with a rich academic and professional background in the field of biotechnology and multi-omics research. He earned both his bachelor's and master's degrees in biotechnology, followed by a Ph.D. in biotechnology from the Motilal Nehru National Institute of Technology (MNNIT), Allahabad, in 2022. His doctoral research focused on the role of microRNAs (miRNA), liquid biopsy techniques, biomarkers, and epigenetic mechanisms in ovarian cancer, contributing to the advancement of early detection and diagnostic methodologies. Following his Ph.D., Dr. Kumar joined the Department of Laboratory Medicine/Pathology at the All India Institute of Medical Sciences (AIIMS), Patna, as a postdoctoral fellow under a Department of Science and Technology (DST) project. Here, his work centered on breast cancer research, where he applied his expertise in molecular diagnostics and cancer biology to explore new avenues for understanding and diagnosing breast cancer. Dr. Kumar's pursuit of excellence then led him to the United States, where he joined the University of South Florida (USF) Microbiome Institute within the Center of Excellence in Aging and Brain Repair as a postdoctoral researcher. His current research delves into the complex interplay between the gut microbiome and the brain, specifically examining how epigenetic modifications influence the gut-brain axis in cognitively impaired patients. By integrating multi-omics approaches, Dr. Kumar aims to uncover the molecular mechanisms underlying cognitive disorders and identify potential biomarkers for early diagnosis and therapeutic intervention. Dr. Vivek Kumar's work stands at the cutting edge of biotechnology, epigenetics, and neurodegenerative disease research, contributing valuable insights into cancer diagnostics and brain health through the lens of microbiome science and molecular biology.

Dr. Amit Chaudhary is currently a postdoctoral scholar in the Department of Cell, Developmental, and Integrative Biology at The University of Alabama at Birmingham, Alabama, USA. Prior to this, Dr. Chaudhary worked as a postdoctoral fellow in the Polymer Simulation and Characterization Lab in the Department of Metallurgical Engineering and Materials Science at the Indian Institute of Technology Bombay, Mumbai, India. He completed his Ph.D. in biotechnology in the Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India. Dr. Chaudhary also holds an M.Tech. in bioinformatics from the Indian Institute of Information Technology, Allahabad, India, and a Bachelor of Pharmacy from the United Institute of Pharmacy, Allahabad, India. Dr. Chaudhary's research interests span a broad range of topics, including transcriptomics analysis, molecular modeling, molecular docking, molecular dynamics simulations, phylogenetic analysis, protein-protein/gene-gene interaction, and functional and pathways analysis of proteins/genes.

維維克·庫馬博士是一位擁有豐富學術和專業背景的博士後研究員，專注於生物技術和多組學研究。他在生物技術領域獲得了學士和碩士學位，並於2022年在印度阿拉哈巴德的莫蒂拉爾·尼赫魯國立技術學院（MNNIT）獲得生物技術博士學位。他的博士研究集中於微小RNA（miRNA）、液體活檢技術、生物標記和表觀遺傳機制在卵巢癌中的作用，為早期檢測和診斷方法的進步做出了貢獻。在獲得博士學位後，庫馬博士加入了印度全國醫學科學院（AIIMS）巴特那的實驗室醫學/病理學系，作為一名博士後研究員，參與了一個科學與技術部（DST）項目。在這裡，他的工作集中於乳腺癌研究，運用他在分子診斷和癌症生物學方面的專業知識，探索理解和診斷乳腺癌的新途徑。庫馬博士追求卓越的精神使他來到美國，加入了南佛羅里達大學（USF）微生物組研究所，成為老化與大腦修復卓越中心的博士後研究員。他目前的研究深入探討腸道微生物組與大腦之間的複雜相互作用，特別是研究表觀遺傳修飾如何影響認知障礙患者的腸腦軸。通過整合多組學方法，庫馬博士旨在揭示認知障礙的分子機制，並識別潛在的生物標記，以便於早期診斷和治療介入。維維克·庫馬博士的工作位於生物技術、表觀遺傳學和神經退行性疾病研究的前沿，通過微生物組科學和分子生物學的視角，為癌症診斷和大腦健康提供了寶貴的見解。

阿米特·喬杜里博士目前是美國阿拉巴馬州伯明翰大學細胞、發展與整合生物學系的博士後學者。在此之前，喬杜里博士曾在印度孟買的印度理工學院孟買分校金屬工程與材料科學系的聚合物模擬與表徵實驗室擔任博士後研究員。他在印度阿拉哈巴德的莫蒂拉爾·尼赫魯國立技術學院生物技術系獲得生物技術博士學位。喬杜里博士還擁有印度阿拉哈巴德信息技術學院的生物信息學碩士學位，以及印度阿拉哈巴德聯合藥學院的藥學學士學位。喬杜里博士的研究興趣涵蓋廣泛的主題，包括轉錄組分析、分子建模、分子對接、分子動力學模擬、系統發育分析、蛋白質-蛋白質/基因-基因相互作用，以及蛋白質/基因的功能和途徑分析。